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Do heart failure status and psychosocial variables moderate the relationship between leisure time physical activity and mortality risk among patients with a history of myocardial infarction? | LitMetric

AI Article Synopsis

  • Leisure time physical activity (LTPA) is linked to a lower mortality risk in patients with a history of myocardial infarction (MI), with the study analyzing data from 1,169 participants over an average follow-up of 8.4 years.
  • While heart failure (HF) status did not impact this relationship, psychosocial factors like levels of depression and social support did, influencing mortality risk differently across various activity levels.
  • Patients engaging in moderate LTPA (1-150 weekly minutes) with high depression showed better survival rates than those with low depression, while a high level of social support improved survival rates for those exercising more than 300 minutes a week.

Article Abstract

Background: Leisure time physical activity (LTPA) is inversely related to mortality risk among patients with a history of myocardial infarction (MI). The aims were to explore if heart failure (HF) status and psychosocial variables moderate the association.

Methods: Participants (n = 1169) were from a multi-center prospective cohort study. Information on LTPA (none, irregular,1-150, 151-300 and >300 weekly minutes), depression, social support and other prognostic indicators were collected 10-13 years after index MI. Cox regressions were conducted, adjusting for potential confounders. In case of significant moderation by HF-status or psychosocial variables, stratified analyses were performed.

Results: During follow-up (M = 8.4 years), 25.6 % of the sample had died. LTPA was inversely associated with mortality (p for trend < 0.01 in all models). HF did not, but psychosocial variables did, moderate the association. In the LTPA category 1-150 weekly minutes, patients with a high level of depression had a lower mortality risk in comparison to those with a low level (hazard ratios (95 % confidence intervals) were 0.43 (0.25, 0.75) versus 0.69 (0.36, 1.32)), and patients with a low level of social support had a lower mortality risk in comparison to those with a high level (0.40 (0.21, 0.77) versus 0.71 (0.39, 1.27)). In the category >300 min, patients with a high level of social support had a lower mortality risk than those with a low level (0.38 (0.19, 0.79) versus 0.51 (0.30, 0.87)).

Conclusions: LTPA was inversely related to mortality risk of post-MI patients. HF did not moderate the relationship; depression and social support partially did.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059913PMC
http://dx.doi.org/10.1186/s12872-016-0363-7DOI Listing

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