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| http://dx.doi.org/10.1183/23120541.00013-2016 | DOI Listing |
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We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.
View Article and Find Full Text PDFPhylogenetic and Pathogenic Analysis of H5N1 and H5N6 High Pathogenicity Avian Influenza Virus Isolated from Poultry Farms (Layer and Broiler Chickens) in Japan in the 2023/2024 Season.
Viruses
December 2024
Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba 3050856, Japan.
During the 2023-2024 winter, 11 high pathogenicity avian influenza (HPAI) outbreaks caused by clade 2.3.4.
View Article and Find Full Text PDFCombination Adjuvants Enhance Recombinant H5 Hemagglutinin Vaccine Protection Against High-Dose Viral Challenge in Chickens.
Vaccines (Basel)
December 2024
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Background: Recombinant avian influenza subunit vaccines often require adjuvants to enhance immune responses. This study aims to evaluate the immune-enhancing potential of seven combination adjuvants in specific pathogen-free (SPF) chickens.
Methods: SPF chickens were vaccinated with combinations of ISA78VG and adjuvants, including Quil-A, CpG, and monophosphoryl lipid A (MPLA).
Mammalian ZAP and KHNYN independently restrict CpG-enriched avian viruses.
bioRxiv
December 2024
Department of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Zoonotic viruses are an omnipresent threat to global health. Influenza A virus (IAV) transmits between birds, livestock, and humans. Proviral host factors involved in the cross-species interface are well known.
View Article and Find Full Text PDFRandom forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus.
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Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, Guangzhou 510642, China. Electronic address:
A switch from avian-type α-2,3 to human-type α-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus. Some H9N2 viruses exhibit a preference for binding to human-type α-2,6 receptors. This identifies their potential threat to public health.
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