Indirect hemagglutination was used to detect the blood serum antibrain antibodies in 472 patients with inflammatory maxillofacial diseases. Long-term follow-up was performed in 109 of the patients. High titres of antibrain antibodies were found. These were most pronounced in patients with concomitant odontogenic phlegmons. The disease severity correlated with the antibrain antibodies titers. The bodily disorders in severe odontogenic infection are accounted for by an "overload syndrome" due to the inflammatory focus influence on the brain and, subsequently, vicious circle formation involving facial inflammation and the brain as the organ of central homeostatic regulation.
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