A rapid and sensitive micro-assay to determine the capacity of quinones to undergo redox cycling.

Toxicol Lett

Department of Pharmacognosy, Faculty of Pharmacy, University of Utrecht, The Netherlands.

Published: August 1989

Using a series of aziridinyl-benzoquinones it is shown that the conversion of oxyhemoglobin to methemoglobin in sheep erythrocytes is correlated with the capacity of each quinone to undergo redox cycling. Based on these findings a semiquantitative assay is developed for the rapid screening of redox cycling quinones.

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http://dx.doi.org/10.1016/0378-4274(89)90169-0DOI Listing

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