Pharmacogenomics harnesses the utility of a patient's genome (n = 1) in decisions on which therapeutic drugs and in what amounts should be administered. Often, patients with shared ancestry present with comparable genetic profiles that predict drug response. However, populations are not static, thus, often, population mobility through migration, especially enmasse as is seen for refugees, changes the pharmacogenetic profiles of resultant populations and therefore observed responses to commonly used therapeutic drugs. For example, in the aftermath of the Syrian civil war since 2011, millions have fled their homes to neighboring countries in the Middle East. The growing permanence of refugees and mass migrations is a call to shift our focus in the life sciences community from old models of pharmaceutical innovation. These seismic social changes demand faster decisions for "population-to-population bridging," whereby novel drugs developed in or for particular regions/countries can meet with rational regulatory decisions/approval in world regions impacted by migrant/refugee populations whose profiles are dynamic, such as in the Eastern Mediterranean region at present. Thus, it is important to characterize and report on the prevalence of pharmacogenes that affect commonly used medications and predict if population changes may call for attention to particular differences that may impact health of patients. Thus, we report here on four single-nucleotide polymorphism (SNP) variations in CYP2C9 and CYP2C19 genes among Mersin-Turkish healthy volunteers in the Mersin Province in the Eastern Mediterranean region that is currently hosting a vast number of migrant populations from Syria. Both CYP2C9 and CYP2C19 are very important pharmacogene molecular targets. We compare and report here on the observed SNP genetic variation in our sample with data on 12 world populations from dbSNP and discuss the feasibility of forecasting the pharmacokinetics of drugs utilized by migrant communities in Mersin and the Eastern Mediterranean region. This study can serve as a catalyst to invest in research in Syrian populations currently living in the Eastern Mediterranean. The findings have salience for rapid and rational regulatory decision-making for worldwide precision medicine and, specifically, "pharmacogenovigilance-guided bridging of pharmacokinetics" across world populations in the current era of planetary scale migration.
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http://dx.doi.org/10.1089/omi.2016.0133 | DOI Listing |
Environ Sci Pollut Res Int
January 2025
The Cyprus Institute, Climate and Atmosphere Research Center, 2121, Nicosia, Cyprus.
The production of nitrogen oxides (NO = NO + NO ) is substantial in urban areas and from fossil fuel-fired power plants, causing both local and regional pollution, with severe consequences for human health. To estimate their emissions and implement air quality policies, authorities often rely on reported emission inventories. The island of Cyprus is de facto divided into two different political entities, and as a result, such emissions inventories are not systematically available for the whole island.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
January 2025
Toxicology Society of Bangladesh, Shugandha R/A, Panchlaish, Chattogram 4203, Bangladesh.
Background: Bangladesh has a high rate of snakebite. In rural areas, there is a significant mortality and morbidity rate due to lack of awareness and inappropriate first aid practices. This study aims to determine the knowledge and practices of the rural population in two subdistricts of Bangladesh regarding snakebite prevention and first aid measures.
View Article and Find Full Text PDFArch Razi Inst
June 2024
Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Mersin 10, Turkey.
The present experimental study aimed to assess the wound healing and anti-inflammatory effects of green synthesized copper nanoparticles (CuNPs) by the methanol extract of (Boiss), as a plant with various pharmacological effects, such as anti-inflammatory and antimicrobial effects, in traditional and modern medicine. The precipitation approach was used for the green synthesis of CuNPs by mixing the methanol and copper sulfate solution. Cell viability and fibroblast proliferation assay were performed by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay.
View Article and Find Full Text PDFJ Headache Pain
December 2024
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Edvard Griegs gate, Trondheim, Norway.
Background: We have previously shown headache disorders to be prevalent in in the adult general population of Morocco, especially migraine (30.8%) and headache on ≥ 15 days/month (H15+; 10.5%).
View Article and Find Full Text PDFArchaeol Anthropol Sci
December 2024
Institut Català d'Arqueologia Clàssica (ICAC-CERCA), Tarragona, ES Spain.
Unlabelled: During the Iron Age, north-eastern Iberian communities relied on crop cultivation and animal husbandry for their subsistence. The latter was mainly focused on caprine, with sheep being prominent due to their suitability to the Mediterranean climate, orography, and environment. Despite the pivotal role of sheep in livestock husbandry, information on Iberian communities' feeding strategies for this species is limited.
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