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Dynamic Tracking Human Mesenchymal Stem Cells Tropism following Smoke Inhalation Injury in NOD/SCID Mice. | LitMetric

AI Article Synopsis

  • This study investigates the behavior and therapeutic effects of human bone marrow-derived mesenchymal stem cells (hBMSCs) in mice with acute lung injury caused by smoke inhalation.
  • The research uses bioluminescence imaging to track hBMSCs, revealing that these cells initially reside in the lungs but also migrate to the abdomen after 24 hours.
  • Results indicate that hBMSCs help reduce lung injury severity, decrease inflammation, and boost growth factor levels in the lungs, suggesting their potential as a treatment option for acute lung injury without needing to differentiate into lung tissue.

Article Abstract

Multiple preclinical evidences have supported the potential value of mesenchymal stem cells (MSCs) for treatment of acute lung injury (ALI). However, few studies focus on the dynamic tropism of MSCs in animals with acute lung injury. In this study, we track systemically transplanted human bone marrow-derived mesenchymal stem cells (hBMSCs) in NOD/SCID mice with smoke inhalation injury (SII) through bioluminescence imaging (BLI). The results showed that hBMSCs systemically delivered into healthy NOD/SCID mouse initially reside in the lungs and then partially translocate to the abdomen after 24 h. Compared with the uninjured control group treated with hBMSCs, higher numbers of hBMSCs were found in the lungs of the SII NOD/SCID mice. In both the uninjured and SII mice, the BLI signals in the lungs steadily decreased over time and disappeared by 5 days after treatment. hBMSCs significantly attenuated lung injury, elevated the levels of KGF, decreased the levels of TNF- in BALF, and inhibited inflammatory cell infiltration in the mice with SII. In conclusion, our findings demonstrated that more systemically infused hBMSCs localized to the lungs in mice with SII. hBMSC xenografts repaired smoke inhalation-induced lung injury in mice. This repair was maybe due to the effect of anti-inflammatory and secreting KGF of hMSCs but not associated with the differentiation of the hBMSCs into alveolar epithelial cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048056PMC
http://dx.doi.org/10.1155/2016/1691856DOI Listing

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