AI Article Synopsis
- - A rare case of nephrotic syndrome (NS) developed in a 50-year-old woman 94 days after umbilical cord transplantation (UBT), requiring dialysis due to oliguria.
- - A kidney biopsy showed focal and segmental glomerulosclerosis, and initial treatment with glucocorticoids was ineffective.
- - The addition of low-density lipoprotein (LDL) apheresis successfully led to remission of NS, significantly improving her kidney function and allowing her to stop dialysis; this is the first documented case linking UBT-associated NS with LDL apheresis treatment.
Article Abstract
The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and segmental glomerulosclerosis. Although glucocorticoid monotherapy did not improve her condition, the addition of low-density lipoprotein (LDL) apheresis resulted in remission of NS, a drastic improvement in her renal function, and withdrawal from dialysis. To the best of our knowledge, this is the first report of UBT-associated NS treated with LDL apheresis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088545 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.55.7017 | DOI Listing |
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