Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243947 | PMC |
| http://dx.doi.org/10.2183/pjab.92.290 | DOI Listing |
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