AI Article Synopsis
- The study investigates the increased cancer risk in patients with type 2 diabetes, emphasizing the need for early detection for better survival outcomes.
- It analyzed data from 203 diabetes patients who developed cancer and compared them to a control group of similar patients without cancer, focusing on various risk factors.
- Key findings showed that high HbA1c levels, obesity, and insulin treatment increased cancer risk, while metformin use lowered it; thus, obese patients with poorly controlled diabetes should be closely monitored for malignancies like breast and colorectal cancer.
Article Abstract
Background: The risk of several types of cancer is increased in type 2 diabetes mellitus. The earliest possible diagnosis of cancer - difficult within regular outpatient diabetes care - is of utmost importance for patients' survival. The aim of this multicenter, retrospective (years 1998-2015), case-control study was to identify risk factors associated with malignancy in subjects with diabetes treated in a typical outpatient setting.
Methods: In the databases of 3 diabetic and 1 primary care clinics 203 patients (115 women) with type 2 diabetes mellitus who developed malignancy while treated for diabetes were identified. The control group consisted of 203 strictly age- and gender matched subjects with type 2 diabetes without cancer. Factors associated with diabetes: disease duration, antidiabetic medications use and metabolic control of diabetes were analyzed. Also other variables: BMI (body mass index), smoking habits, place of residence and comorbidities were included into analysis.
Results: The most prevalent malignancies in men and women together were breast cancer (20.7 %) and colorectal cancer (16.3 %). HbA (hemoglobin A) level ≥8.5 %, obesity and insulin treatment in dose-dependent and time-varying manner demonstrated significant association with increased risk of malignancy, while metformin use was associated with a lower risk of cancer. Diabetes duration, comorbidities, smoking habits, place of residence and aspirin use did not show significant association with risk of malignancy.
Conclusions: In the outpatient setting the obese patients with poorly controlled insulin treated type 2 diabetes mellitus should be rigorously assessed towards malignancies, particularly breast cancer in women and colorectal cancer in men.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057369 | PMC |
| http://dx.doi.org/10.1186/s12885-016-2836-6 | DOI Listing |
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