barley dietary fibre reduces body fat and increases insulin sensitivity in model.

barley (PWB) is high in β-glucan with moderate content of resistant starch. PWB reduced intestinal fat deposition (IFD) in wild type , N2), and in or null mutants, and sustained a surrogate marker of lifespan, pharyngeal pumping rate (PPR), in N2, , or mutants. Hyperglycaemia (2% glucose) reversed or reduced the PWB effect on IFD in N2 or mutants with a sustained PPR. mRNA expression of , and were dose-dependently reduced in N2 or mutants, elevated in mutants with reduction in , and unchanged in mutants. mRNA expressions were increased by hyperglycaemia in N2 or mutants, while reduced in or mutants. The effects of PWB in the model appeared to be primarily mediated via , and . These data suggest that PWB and β-glucans may benefit hyperglycaemia-impaired lipid metabolism.