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Components of Adenovirus Genome Packaging. | LitMetric

Components of Adenovirus Genome Packaging.

Front Microbiol

Department of Comparative Pathobiology, Purdue UniversityWest Lafayette, IN, USA; Purdue University Center for Cancer Research, Purdue UniversityWest Lafayette, IN, USA; Purdue Institute for Immunology, Inflammation and Infectious Diseases, Purdue UniversityWest Lafayette, IN, USA.

Published: September 2016

AI Article Synopsis

Article Abstract

Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes. Genome packaging in AdV is thought to be similar to that seen in dsDNA containing icosahedral bacteriophages and herpesviruses. Specific recognition of the AdV genome is mediated by a packaging domain located close to the left end of the viral genome and is mediated by the viral packaging machinery. Our understanding of the role of various components of the viral packaging machinery in AdV genome packaging has greatly advanced in recent years. Characterization of empty capsids assembled in the absence of one or more components involved in packaging, identification of the unique vertex, and demonstration of the role of IVa2, the putative packaging ATPase, in genome packaging have provided compelling evidence that AdVs follow a sequential assembly pathway. This review provides a detailed discussion on the functions of the various viral and cellular factors involved in AdV genome packaging. We conclude by briefly discussing the roles of the empty capsids, assembly intermediates, scaffolding proteins, portal vertex and DNA encapsidating enzymes in AdV assembly and packaging.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033970PMC
http://dx.doi.org/10.3389/fmicb.2016.01503DOI Listing

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