Prognosis of Prolonged Intensive Care Unit Stay After Aortic Valve Replacement for Severe Aortic Stenosis in Octogenarians.

J Cardiothorac Vasc Anesth

Département d'Anesthésie Réanimation Chirurgicale, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique-Hôpitaux de Paris, Université Paris 7, Denis Diderot, Paris, France; ‡Service d'Anesthésie, Institut Mutualiste Montsouris, Paris, France.

Published: December 2016

AI Article Synopsis

  • Octogenarians undergoing cardiac surgery experience more complications than younger patients, prompting concerns about the cost-effectiveness of their care given their limited life expectancy.
  • A study focused on patients over 80 years old undergoing aortic valve replacement evaluated mortality rates linked to extended ICU stays and determined that a 4-day length of stay is the optimal cut-off for identifying prolonged hospitalization.
  • Key risk factors for complications included low ventricular ejection fraction, coronary disease, and the need for catecholamines, but prolonged ICU stays without organ failure did not lead to higher mortality rates.

Article Abstract

Objectives: Octogenarians considered for cardiac surgery encounter more complications than other patients. Postoperative complications raise the question of continuation of high-cost care for patients with limited life expectancy. Duration of hospitalization in intensive care after cardiac surgery may differ between octogenarians and other patients. The objectives were evaluating the mortality rate of octogenarians experiencing prolonged hospitalization in intensive care and defining the best cut-off for prolonged intensive care unit length of stay.

Design: A single-center observational study.

Setting: A postoperative surgical intensive care unit in a tertiary teaching hospital in Paris, France.

Participants: All consecutive patients older than 80 years considered for aortic valve replacement for aortic stenosis were included.

Measurements And Main Results: Mortality rate was determined among patients experiencing prolonged stay in intensive care with organ failure and without organ failure. An ROC curve determined the optimal cut-off defining prolonged hospitalization in intensive care according to the occurrence of postoperative complications. Multivariate analysis determined risk factors for early death or prolonged intensive care stay. The optimal cut-off defining prolonged intensive care unit length of stay was 4 days. Low ventricular ejection fraction (odds ratio [OR] = 0.95; 95% confidence interval [CI] 0.96-0.83; p = 0.0016), coronary disease (OR = 2.34; 95% CI 1.19-4.85; p = 0.014), and need for catecholamine (OR = 2.79; 95% CI 1.33-5.88; p = 0.0068) were associated with eventful postoperative course. There was not a hospitalization duration beyond which the prognosis significantly worsened.

Conclusions: Prolonged length of stay in ICU without organ failure is not associated with increased mortality. No specific duration of hospitalization in intensive care was associated with increased mortality. Continuation of care should be discussed on an individual basis.

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.jvca.2016.07.029DOI Listing

Publication Analysis

Top Keywords

intensive care
40
prolonged intensive
16
care unit
16
hospitalization intensive
16
care
12
organ failure
12
intensive
10
aortic valve
8
valve replacement
8
aortic stenosis
8

Similar Publications

Rural and remote health care: the case for spatial justice.

Rural Remote Health

January 2025

School of Health Sciences, Western Sydney University, Campbelltown, NSW 2560, Australia.

Almost universally, people living in rural and remote places die younger, poorer, and sicker than urban-dwelling citizens of the same country. Despite clear need, health services are commonly less available, and more costly and challenging to access, for rural and remote people. Rural geography is commonly cited as a reason for these disparities, that is, rural people are said to live in places too distant, too underpopulated, and too difficult to access.

View Article and Find Full Text PDF

Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the pharmacokinetics and pharmacodynamics of a protein cargo. Affinity targeting of Factor IX (FIX) to the RBC membrane is a promising approach to improve the (pro)enzyme's pharmacokinetics. For RBC targeting, purified human FIX was conjugated to the anti-mouse glycophorin A monoclonal antibody Ter119.

View Article and Find Full Text PDF

Influenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospitalization, intensive care unit (ICU) admission and in-hospital mortality in Spain over five seasons (2015-2020) via publicly available Minimum Basic Datasets (MDBS).

View Article and Find Full Text PDF

Background: With the increasing implementation of patient online record access (ORA), various approaches to access to minors' electronic health records have been adopted globally. In Sweden, the current regulatory framework restricts ORA for minors and their guardians when the minor is aged between 13 and 15 years. Families of adolescents with complex health care needs often desire health information to manage their child's care and involve them in their care.

View Article and Find Full Text PDF

Background: Acute pain management is critical in postoperative care, especially in vulnerable patient populations that may be unable to self-report pain levels effectively. Current methods of pain assessment often rely on subjective patient reports or behavioral pain observation tools, which can lead to inconsistencies in pain management. Multimodal pain assessment, integrating physiological and behavioral data, presents an opportunity to create more objective and accurate pain measurement systems.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!