Small airways disease, or bronchiolitis, encompasses many conditions that result in bronchiolar inflammation and/or fibrosis. Bronchioles are distal airways within secondary pulmonary lobules that are only visible on imaging when abnormal. High-resolution computed tomography plays an important role in diagnosing small airways disease. The predominant direct high-resolution computed tomography sign of bronchiolitis includes centrilobular nodules, whereas air trapping is the main indirect finding. This article reviews bronchiolar anatomy, discusses the differential diagnosis for cellular and constrictive bronchiolitis with a focus on key imaging features, and discusses how to distinguish important mimics.
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