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scSMD: a deep learning method for accurate clustering of single cells based on auto-encoder.
BMC Bioinformatics
January 2025
Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Single-cell RNA sequencing (scRNA-seq) has transformed biological research by offering new insights into cellular heterogeneity, developmental processes, and disease mechanisms. As scRNA-seq technology advances, its role in modern biology has become increasingly vital. This study explores the application of deep learning to single-cell data clustering, with a particular focus on managing sparse, high-dimensional data.
View Article and Find Full Text PDFSystematic Literature Review on Public Health Impacts of Persistent Tic Disorders: Health Care Needs and Health Care Use.
Psychiatr Clin North Am
March 2025
Applied Research and Evaluation Team, Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), 4770 Buford Hwy S106-4, Atlanta, GA 30341, USA.
This study describes our systematic literature review documenting outcomes associated with persistent tic disorders (PTDs) and summarizes 15 articles comparing health care use between individuals with PTDs and a comparison group without PTDs. Only 2 studies included adults and only one study stratified findings by sociodemographic characteristics, precluding conclusions on health care disparities. Most children with PTDs had access to routine care, similar to children without PTDs, but needed and used more specialty health care, including mental health services, compared to children without PTDs.
View Article and Find Full Text PDFBarH1 regulates the expression of conserved odorant-binding protein 22 from Dastarcus helophoroides.
Insect Biochem Mol Biol
January 2025
Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Chemical signals are pivotal in establishing tritrophic interactions among host plants, herbivorous insects, and natural enemies. Previous studies have shown that evolutionarily conserved MaltOBPs in Monochamus alternatus and DhelOBPs in Dastarcus helophoroides contribute to the establishment of pine -pest - natural enemy tritrophic interactions by recognizing the same volatile emitted by the host during crucial developmental stages. We hypothesized that the transcriptional regulatory mechanisms of evolutionarily conserved OBPs respectively from pests and enemies are similar.
View Article and Find Full Text PDFTemperature-driven development and reproduction in Cacopsylla citrisuga (Hemiptera: Psyllidae): insights from an age-stage, two-sex life table analysis.
J Econ Entomol
January 2025
Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, P.R. China.
The citrus pest Cacopsylla citrisuga (Yang & Li), a vector for Citrus Huanglongbing (HLB), exhibits distinct sensitivity to temperature variations. This study utilized an age-stage, 2-sex life table to evaluate the development and reproduction of C. citrisuga across 5 temperatures (17, 20, 25, 28, and 31 °C).
View Article and Find Full Text PDFObjective: Countertransference (CT) has been shown to interfere with therapy goals, and its management is crucial to desired treatment outcomes. As a first step, a clinician's awareness of their covert and overt CT reactions is critical to successfully managing CT. Research on CT awareness is scarce, however, mainly because of difficulties in empirically investigating and measuring this construct.
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