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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria.
Nat Commun
December 2024
Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Conjugative plasmids promote the dissemination and evolution of antimicrobial resistance in bacterial pathogens. However, plasmid acquisition can produce physiological alterations in the bacterial host, leading to potential fitness costs that determine the clinical success of bacteria-plasmid associations. In this study, we use a transcriptomic approach to characterize the interactions between a globally disseminated carbapenem resistance plasmid, pOXA-48, and a diverse collection of multidrug resistant (MDR) enterobacteria.
View Article and Find Full Text PDFTime trends in malaria incidence from 1992 to 2021 in high-risk regions: an age‑period‑cohort analysis based on the Global Burden of Disease study 2021.
Int J Infect Dis
December 2024
Department of Epidemiology & Health Statistics, School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang, China. Electronic address:
Objectives: Malaria, caused by plasmodium parasites, remains one of the world's most significant infectious diseases due to its high incidence and mortality. This study aims to analyze malaria incidence globally, identify high-risk regions, and examine long-term trends in incidence to provide important evidence for malaria eradication.
Methods: We used data from the Global Burden of Disease Study (GBD) 2021, applying the age-period-cohort model to estimate the effects of age, period and cohort on malaria incidence from 1992 to 2021.
Empowering women's health: a rising priority.
Hong Kong Med J
December 2024
The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Efficacy of fisheries management strategies in mitigating ecological, social, and economic risks of climate warming in China.
J Environ Manage
December 2024
School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY, 11794, USA.
Climate change has significantly altered fish population dynamics and marine ecosystems worldwide, resulting in multiple ecological, economic and social risks for sustainable fisheries. As a hotspot of global warming, China is anticipated to face with extensive climate-driven changes in marine fisheries and ecosystems, but a clear and adaptative management strategy has not been established. In this study, we assessed the climate adaptiveness of current fisheries management and alternative strategies with diverse management priorities.
View Article and Find Full Text PDFRetrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches.
Sci Rep
December 2024
Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, 1082, Hungary.
Human alveolar echinococcosis (HAE), which is caused by the larval stage of the Echinococcus multilocularis tapeworm, is an increasing healthcare issue in Hungary. Among the 40 known cases in the country, 25 were detected in the last five years. Our study aimed to reveal the geographically underlying risk factors associated potentially with these cases.
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