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Exploring the therapeutic potential of precision medicine in rare genetic obesity disorders: a scientific perspective.
Front Nutr
December 2024
Faculty of Medicine, Diabetes Center, University of Geneva, Geneva, Switzerland.
The prevalence of obesity is increasing worldwide, affecting both children and adults. This obesity epidemic is mostly driven by an increase in energy intake (abundance of highly palatable energy-dense food and drinks) and to a lesser degree a decrease in energy expenditure (sedentary lifestyle). A small proportion of individuals with obesity are affected by genetic forms of obesity, which often relate to mutations in the leptin-melanocortin pathway or are part of syndromes such as the Bardet-Biedl syndrome.
View Article and Find Full Text PDFEditorial: Biological Therapies and Eating Disorders.
Eur Eat Disord Rev
December 2024
Department for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Austria.
Article Synopsis
- - Blood-based biomarkers and neuroimaging are enhancing our understanding and diagnosis of eating disorders (EDs).
- - The editorial introduces a collection discussing novel biological treatment approaches, including therapies like theta burst stimulation and various pharmacological and microbiome-based treatments.
- - Future research into brain areas linked to memory, emotions, and immune functions may lead to more effective biological treatments for EDs.
Use of a Dual GIP/GLP-1 Receptor Agonist in HNF1A-MODY and HNF4A-MODY.
Diabetes Care
September 2024
Division of Internal Medicine, Department of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI.
Article Synopsis
- * A study involved 33 physicians from six countries who shared their experiences with diagnosing and managing lipodystrophy, highlighting themes like diagnostic challenges, impact on patient quality of life, treatment approaches, and barriers to accessing certain therapies.
- * The findings revealed that lipodystrophy cases are often misdiagnosed or overlooked, delaying treatment; physicians recommended early referrals to specialist teams, acknowledging the significant effects on patients' mental health and self-image.
Partial lipodystrophy: Clinical presentation and treatment.
Ann Endocrinol (Paris)
June 2024
Inserm U938, Centre de recherche Saint-Antoine, Institut de cardiométabolisme et nutrition (ICAN), Sorbonne université, Paris, France; Service d'endocrinologie, hôpital Saint-Antoine, Centre de référence des maladies rares de l'insulino-sécrétion et de l'insulino-sensibilité (PRISIS), Assistance publique-Hôpitaux de Paris (AP-HP), Paris, France.
Article Synopsis
- - Lipodystrophic syndromes are rare diseases, either acquired or genetic, that cause a significant lack of fat tissue, leading to severe metabolic issues like insulin resistance and high triglycerides.
- - These syndromes can be underdiagnosed, especially in partial forms, where individuals may still have some fat but experience additional problems due to excess fat in certain body areas.
- - Diagnosis involves clinical evaluations and metabolic tests, and early lifestyle changes alongside tailored medical support are crucial; in some cases, the medication metreleptin may be prescribed if other treatments fail.
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