Background: Several studies have suggested that periodontal disease can exacerbate the pro-inflammatory status of the brain. Tooth loss is one of the alternative evaluation indices of periodontal disease. There are few data on the relationship between tooth loss and memory impairment, depending on the apolipoprotein E (APOE) ɛ4 genotype.
Objective: To determine if tooth loss is associated with mild memory impairment (MMI) and if this association is modified by the presence of the APOEɛ4 allele.
Methods: A nested case-control study was conducted from 2007 to 2012 in Japan. Five hundred and thirty-seven Japanese subjects aged 65 years and over who were cognitively intact at baseline were analyzed. MMI at follow-up was evaluated.
Results: The median number of teeth at baseline was significantly lower in MMI participants (n = 179) than in controls (n = 358) (MMI: median 21.0, interquartile range 10.0-25.0 versus controls: 24.0, 14.0-27.0). After adjustment for demographics, vascular risk factors, and APOEɛ4 allele, the multivariate adjusted odds ratio (OR) of ≤8 teeth was 1.97 (95% confidence interval [CI], 1.13-3.44) compared to 25-32 teeth. Participants with both the presence of at least 1 APOEɛ4 allele and ≤8 teeth had a higher risk of MMI compared with those with neither (OR, 2.82; 95% CI, 1.15-6.91). Those with either risk factor alone did not have a higher risk of MMI.
Conclusions: A lower number of teeth is related to risk of MMI. This may be primarily true for those individuals with an APOEɛ4 allele.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147497 | PMC |
| http://dx.doi.org/10.3233/JAD-160638 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterisation of equine odontoclastic tooth resorption and hypercementosis: A comparative study using microCT and radiography in age-matched controls.
Equine Vet J
January 2025
University of Liverpool, Institute of Life Course and Medical Sciences, Liverpool, UK.
Background: Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a painful disorder primarily affecting the incisor teeth of horses over 15 years of age. Clinical signs of the disease include prehension problems, halitosis and in severe cases weight loss. The disease predominately affects the reserve crown and presents as a loss of dental tissue and excessive build-up of cementum.
View Article and Find Full Text PDFDental Implant Rehabilitation in Patients Carrying WNT10A Mutations With Different Molecular Statuses and Phenotypes: A Retrospective Cohort Study.
Clin Oral Implants Res
January 2025
Second Dental Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objectives: WNT10A mutations are associated with tooth agenesis. This study aimed to assess the clinical outcomes of dental implants in patients carrying WNT10A mutations with different molecular statuses and phenotypes over a long-term follow-up period.
Materials And Methods: Patients with tooth agenesis were screened by whole-exome sequencing (WES) from January 2010 to September 2023.
Role of FOXO3a in LPS-induced inflammatory conditions in human dental pulp cells.
J Oral Biosci
January 2025
Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju, Korea. Electronic address:
Objectives: We investigated the involvement of FOXO3a in lipopolysaccharide (LPS)-induced inflammation in primary human dental pulp cells (HDPCs).
Methods: HDPCs that were isolated from donors undergoing tooth extraction for orthodontic purposes were cultured with or without 1 μg/mL LPS at various intervals. The FOXO3a localization in the HDPCs was verified using immunofluorescence.
Anaerobic Adhesive Effect on the Counter-Torque of Zirconia Implant Abutment Screws: In Vitro Study.
Clin Implant Dent Relat Res
February 2025
Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Introduction: Implantology has become a primary solution for tooth loss due to excellent osseointegration and high long-term success rates. However, complications such as abutment screw loosening, especially in implant-supported single crowns, compromise prosthesis longevity. Anaerobic adhesives (AAs) have shown promise in mechanical fields for preventing screw loosening, but their effectiveness in dental implants, particularly zirconia, remains uncertain.
View Article and Find Full Text PDFComparative Analysis Between Strip and Gels Indicated for at Home Bleaching: Analysis of Color Alteration, Roughness and Microhardness of Dental Enamel.
J Esthet Restor Dent
January 2025
Department of Preventive and Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry Araçatuba, Sao Paulo, Brazil.
Purpose: To compare the color alteration, surface roughness and microhardness and cross-sectional microhardness of bovine enamel treated with at-home whitening strips and gels.
Materials And Methods: Sixty-six pigmented specimens (n = 11) were allocated to six groups: C-cotton wool moistened with distilled water for 1 h; SDS-sodium dithionite strip, for 1 h; HPS-6.5% hydrogen peroxide strip, for 1 h; CPS-20% carbamide peroxide strip, for 1 h; HPG-7.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!