Influence of lithium on luminol amplified chemiluminescence activity of leucocytes of human peripheral blood was studied by a continuously recorded system. Lithium had a biphasic effect on mitogen-induced early activation of mononuclear cells, i.e. at concentration of 1.0 mM an increase, at higher concentrations a significant inhibition in photon emission was observed. Activating the mononuclear cells by opsonized Zymosan in the presence of lithium a dose-dependent decrease of chemiluminescence was registered. The respiratory burst of polymorphonuclear granulocytes induced by either mitogen or opsonized Zymosan was significantly inhibited at 2.0 and 5.0 mM of lithium, respectively. Chemiluminescence activity of peroxidase-dependent and independent cell-free system was not influenced by lithium. It was concluded that lithium by accumulating into target organs might have an immunosuppressive and antiphlogistic effect by mean of inhibition of antigen-presenting cells and polymorphonuclear granulocytes.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cellular Response of Immune Cells in the Upper Respiratory Tract After Treatment with Cold Atmospheric Plasma In Vitro.
Int J Mol Sci
December 2024
Department of Dermatology, University Medical Center Regensburg, 93053 Regensburg, Germany.
Cold atmospheric plasma (CAP) has antimicrobial properties and is also known to stimulate the immune system. These properties could be useful for the development of a novel therapeutic or preventive strategy against respiratory infections in the upper respiratory tract (URT) such as ventilator-associated pneumonia (VAP) without inducing an immune overreaction. This study investigated the cellular responses of polymorphonuclear neutrophils (PMNs) after exposure to CAP in a three-dimensional (3D) model of the URT.
View Article and Find Full Text PDFProton pump inhibitor effect on macrophage and neutrophil function: a systematic review.
Front Immunol
January 2025
College of Pharmacy, University of Houston, Houston, TX, United States.
Background: Proton pump inhibitors (PPIs) are one of the most used drugs worldwide. While generally considered safe, the usage of PPIs is associated with several adverse outcomes including acute infectious diseases. PPIs influence macrophage and neutrophil function although a systematic review has never been undertaken.
View Article and Find Full Text PDFKSRP Deficiency Attenuates the Course of Pulmonary Aspergillosis and Is Associated with the Elevated Pathogen-Killing Activity of Innate Myeloid Immune Cells.
Cells
December 2024
Department of Dermatology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
The mRNA-binding protein KSRP (KH-type splicing regulatory protein) is known to modulate immune cell functions post-transcriptionally, e.g., by reducing the mRNA stability of cytokines.
View Article and Find Full Text PDFBovine PMN responses to extracellular vesicles released by tachyzoites and -infected host cells.
Front Immunol
January 2025
Institute of Parasitology, Justus Liebig University Giessen, Giessen, Germany.
Bovine besnoitiosis is a re-emerging cattle disease caused by the apicomplexan parasite , which severely affects individual animal welfare and profitability in cattle industry. We recently showed that tachyzoite exposure to bovine polymorphonuclear neutrophils (PMN) effectively triggers neutrophil extracellular trap (NET) formation, leading to parasite immobilization hampering host cell infection. So far, the triggers of this defense mechanism remain unclear.
View Article and Find Full Text PDFPolymorphonuclear myeloid-derived suppressor cells regulates immune recovery during HIV infection through PD-L1 and TGF-β pathways.
Front Cell Infect Microbiol
January 2025
Department of Infectious Diseases, Tianjin Second People's Hospital, Tianjin, China.
Background: Although MDSCs are widely recognized for their immunoinhibitory effects in pathological conditions, their function during HIV infection particularly within the mechanisms underlying incomplete immune recovery remains elusive.
Methods: We conducted a cross-sectional study in which 30 healthy controls and 62 HIV-1-infected subjects [31 immunological non-responders (INRs) and 31 immunological responders (IRs)] were selected. The proportion of MDSCs was determined in each category of participants.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!