In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC values that are in the same range as of Sofosbuvir.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079539 | PMC |
| http://dx.doi.org/10.1039/c6ob01189f | DOI Listing |
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