δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.

Gregor Carpentero Burdeos Junya Ito Takahiro Eitsuka Kiyotaka Nakagawa Fumiko Kimura Teruo Miyazawa

Food Funct

Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan. and Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, Japan.

Published: October 2016

Tocotrienol (T3) has recently gained increasing interest due to its anti-cancer effect. Here, we investigated the modulating effect of δ and γ T3 on the Ras-Raf-MEK-ERK oncogenic upstream signaling pathway in human hepatocellular carcinoma HepG2 cells. The results indicated that T3 regulated the upstream signaling cascades of this pathway.

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http://dx.doi.org/10.1039/c6fo00826g	DOI Listing

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