DNA N-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059759 | PMC |
| http://dx.doi.org/10.1038/ncomms13052 | DOI Listing |
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