Metal ion complexes are playing an increasing role in the development of antimicrobials. We review here the antimicrobial properties of cobalt coordination complexes in oxidation state 3+. In addition to reviewing the cobalt complexes containing polydentate donor ligands, we also focus on the antimicrobial activity of the homoleptic [Co(NH₃)₆] ion.
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http://dx.doi.org/10.3390/ph3061711 | DOI Listing |
PLoS One
December 2024
Guangdong Provincial Hospital of Chinese Medicine (Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Background: Further evidence is required regarding the influence of metal mixture exposure on mortality. Therefore, we employed diverse statistical models to evaluate the associations between eight urinary metals and the risks of all-cause and cardiovascular mortality.
Methods: We measured the levels of 8 metals in the urine of adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018.
Inorg Chem
December 2024
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Density functional theory (DFT) calculations indicate that [Co(HO)] reacts with two HO molecules to form [(HO)Co(OOH)(HO)] reactant complexes, which decompose through three distinct pathways depending on the relative orientation between the coordinated OOH and HO ligands. The reactive intermediates produced via these activation pathways include hydroperoxyl (OOH)/superoxide (O) radicals, singlet oxygen (O), and Co(III) species [(HO)Co(O)], [(HO)Co(OH)], and [(HO)Co(OH)]. The Co(III) species display from moderate to strong oxidizing abilities that have long been overlooked.
View Article and Find Full Text PDFJ Environ Manage
December 2024
Environmental Engineering Division, Department of Civil Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, 600036, India. Electronic address:
The release of toxic chemical dyes from the industrial effluent poses huge challenges for the environmental engineers to treat it. Azo dyes encompass the huge part of textile discharges which are difficult to degrade due to their complex chemical aromatic structures and due to the presence of strong bonds (-N=N-). Thus, the removal of a carcinogenic azo dye (i.
View Article and Find Full Text PDFAnal Chem
December 2024
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Among the various aflatoxin B1 (AFB1) assays, performing accurate detection is difficult because false positives and false negatives are frequent due to limited sensitivity, expensive equipment, or inadequate pretreatment during operation. Here, an "off-on" switch-type electrochemiluminescence (ECL) aptasensor armed with cobalt-sulfur quantum dots was encapsulated in hollow cobalt-layered double hydroxide nanocages as an enhanced luminescent probe (Co-LDH@QDs), and a ferrocene-modified aptamer (Fc-APT) was used as a luminescent quencher. In general, when Fc-APT was hybridized with complementary DNA modified with a DNA nanotetrahedron, electron transfer between ferrocene and Co-LDH@QDs was facilitated, leading to efficient quenching of the ECL intensity into an "off" state in the absence of AFB1.
View Article and Find Full Text PDFJ Contemp Brachytherapy
October 2024
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: Non-melanoma skin cancer (NMSC) is the most prevalent cancer worldwide, particularly affecting head and neck region. Surgical excision, especially Moh's microsurgery, is the gold standard for treatment. However, certain patients' factors, such as age, comorbidities, and tumor location, require alternative therapies.
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