AI Article Synopsis
- * Several hydroxycyclohexanol amide derivatives (specifically compounds 14, 18, 24, 29, 31, and 33) showed promising activity in inhibiting these targets during in vitro tests.
- * Among these, compound 24 was highlighted for its good systemic availability and lack of toxicity in animal models, demonstrating potential effectiveness in treating conditions like asthma, COPD, and uveitis.
Article Abstract
Herein we report the synthesis, PDE-4B and TNF-α inhibitory activities of a few dibenzo[b,d]furan-1-yl-thiazole derivatives. The hydroxycyclohexanol amide derivatives 14, 18, 24, 29, 31 and 33 exhibited promising in vitro PDE-4B and TNF-α inhibitory activities. Compound 24 showed good systemic availability in preclinical animal models and was also found to be non-toxic (exploratory mutagenicity test). Further it exhibited promising results in in vivo asthma/COPD and Uveitis models.
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| http://dx.doi.org/10.1016/j.bmc.2016.09.011 | DOI Listing |
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