THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838694 | PMC |
http://dx.doi.org/10.3727/096504016X14685034103194 | DOI Listing |
Front Oncol
June 2021
Department of Spine Surgery, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Objectives: Osteosarcoma (OS) is a type of bone malignancy. This study attempted to explore the effect of long non-coding RNA TTN-AS1 (TTN-AS1) on OS and to determine its molecular mechanisms.
Methods: The expression of TTN-AS1, microRNA-16-1-3p (miR-16-1-3p), and transcription factor activating enhancer binding protein 4 (TFAP4) in OS was assessed using qRT-PCR.
Front Cell Dev Biol
January 2021
College of Medicine, Yanbian University, Yanji, China.
[This corrects the article DOI: 10.3389/fcell.2020.
View Article and Find Full Text PDFFront Cell Dev Biol
December 2020
College of Medicine, Yanbian University, Yanji, China.
The Warburg effect (aerobic glycolysis) is a hallmark of cancer and is becoming a promising target for diagnosis and therapy. Phosphoglycerate kinase 1 (PGK1) is the first adenosine triphosphate (ATP)-generating glycolytic enzyme in the aerobic glycolysis pathway and plays an important role in cancer development and progression. However, how microRNAs (miRNAs) regulate PGK1-mediated aerobic glycolysis remains unknown.
View Article and Find Full Text PDFGenes Nutr
April 2018
2Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Background: The presence of chemotherapy-resistant colorectal cancer stem cells (CCSCs) with KRAS mutation is thought to be one of the primary causes for treatment failure in colorectal cancer (CRC). P53, survivin, and microRNA-16-1 are challenging targets for anticancer drugs which are associated with chemoresistance in CRC. Yet, no p53-, survivin-, and microRNA-16-1-modulating drug with low toxicity but high efficacy against KRAS-mutant CCSCs have been approved for clinical application in CRC.
View Article and Find Full Text PDFPathol Oncol Res
July 2018
Department of Oncology, The Second Hospital, Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian, 116027, China.
Chemotherapy can prevent metastasis and recurrence of gastric cancer (GC), and is a well supplement for operation. But, chemotherapy resistance has severely restricted the application of chemotherapy. This study aimed to investigate the regulatory roles and molecular mechanism of miR-16-1 to the chemosensitivity to adriamycin in GC.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!