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Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis.
J Transl Med
January 2025
College of Life Science, Henan Normal University, Xinxiang, Henan, China.
Background: Regeneration plays a key role in energy recycling and homeostasis maintenance. Planarians, as ideal model animals for studying regeneration, stem cell proliferation, and apoptosis, have the strong regenerative abilities. Considerable evidence suggests that ubiquitin plays an important role in maintaining homeostasis and regulating regeneration, but the function of Ubiquitin specific proteases 7 (Usp7) on regeneration in planarians remains elusive.
View Article and Find Full Text PDFThe relationship between trajectories of intrinsic capacity and differences in the risk of functional ability decline in community-dwelling older adults: A socio-ecological approach.
Arch Gerontol Geriatr
January 2025
College of Nursing, Seoul National University, Seoul, Republic of Korea; Research Institute of Nursing Science, Seoul National University, Seoul, Republic of Korea. Electronic address:
Background: Functional ability (FA), a key determinant of healthy aging, is determined by intrinsic capacity (IC), environmental factors, and their interactions. IC is a composite of physical and mental capacities that undergo constant change. Therefore, understanding the factors that influence IC requires a multi-level analysis of individuals to optimize its trajectory.
View Article and Find Full Text PDFLong-term care plan recommendation for older adults with disabilities: a bipartite graph transformer and self-supervised approach.
J Am Med Inform Assoc
January 2025
Institute of Intelligent Rehabilitation Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Background: With the global population aging and advancements in the medical system, long-term care in healthcare institutions and home settings has become essential for older adults with disabilities. However, the diverse and scattered care requirements of these individuals make developing effective long-term care plans heavily reliant on professional nursing staff, and even experienced caregivers may make mistakes or face confusion during the care plan development process. Consequently, there is a rigid demand for intelligent systems that can recommend comprehensive long-term care plans for older adults with disabilities who have stable clinical conditions.
View Article and Find Full Text PDFRisk prediction models for depression in patients with coronary heart disease: a systematic review and meta-analysis.
Front Cardiovasc Med
January 2025
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Risk prediction models for depression in patients with coronary heart disease are increasingly being developed. However, the quality and applicability of these models in clinical practice remain uncertain.
Objective: To systematically evaluate depression risk prediction models in patients with coronary heart disease (CHD).
Assessing Caregiver Burden, Tasks, and Heart Rate Using Wearable Sensors: A Longitudinal Study of Informal Caregivers of Persons With Dementia and Older Adults.
Cureus
January 2025
Graduate School of Medicine, Mie University, Tsu, JPN.
Purpose In recent years, research on caregivers has highlighted the importance of integrating advanced technologies, such as wearable devices. Furthermore, when investigating the characteristics of persons with dementia (PWD), comparative analyses should be conducted based on the presence or absence of the condition. We aimed to elucidate the relationship between caregivers' subjective burdens, tasks, and heart rate (HR) using wearable sensors to objectively assess the health status of caregivers of PWD and older adults requiring long-term care.
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