Under carbonylative conditions, neutral Rh(I)-systems modified with weak donor ligands (AsPh or 1,4-oxathiane) undergo N-Cbz, N-benzoyl, or N-Ts directed insertion into the proximal C-C bond of aminomethylcyclopropanes to generate rhodacyclopentanone intermediates. These are trapped by N-tethered alkenes to provide complex perhydroisoindoles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073370 | PMC |
| http://dx.doi.org/10.1021/jacs.6b08608 | DOI Listing |
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