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The Effects of Anthropogenic Stressors on Above- and Belowground Phytochemical Diversity of the Wetland Grass, .
Plants (Basel)
November 2024
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Coastal wetlands face threats from climate change-induced flooding and biological invasions. Plants respond to these stressors through changes in their phytochemical metabolome, but it is unclear whether stressors affecting one tissue compartment (e.g.
View Article and Find Full Text PDFImmunometabolic adaptation in monocytes underpins functional changes during pregnancy.
iScience
May 2024
Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, Wales, UK.
Metabolic heterogeneity is a determinant of immune cell function. The normal physiological metabolic reprogramming of pregnancy that ensures the fuel requirements of mother and baby are met, might also underpin changes in immunity that occur with pregnancy and manifest as altered responses to pathogens and changes to autoimmune disease symptoms. Using peripheral blood from pregnant women at term, we reveal that monocytes lose M2-like and gain M1-like properties accompanied by reductions in mitochondrial mass, maximal respiration, and cardiolipin content in pregnancy; glycolysis is unperturbed.
View Article and Find Full Text PDFVegetation dieback in the Mississippi River Delta triggered by acute drought and chronic relative sea-level rise.
Nat Commun
April 2024
Department of Oceanography and Coastal Sciences, Louisiana State University, Baton Rouge, LA, USA.
Vegetation dieback and recovery may be dependent on the interplay between infrequent acute disturbances and underlying chronic stresses. Coastal wetlands are vulnerable to the chronic stress of sea-level rise, which may affect their susceptibility to acute disturbance events. Here, we show that a large-scale vegetation dieback in the Mississippi River Delta was precipitated by salt-water incursion during an extreme drought in the summer of 2012 and was most severe in areas exposed to greater flooding.
View Article and Find Full Text PDFLoss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer.
Mol Metab
March 2024
Institute of Life Science, Swansea University Medical School, Faculty of Medicine, Health & Life Science, Swansea University, Swansea, SA2 8PP, United Kingdom. Electronic address:
The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of cases and reduced MPC1 mRNA expression. To explore the metabolic effect of reduced expression, we demonstrate that depleting MPC1 in HGSOC cell lines drives expression of key proline biosynthetic genes; PYCR1, PYCR2 and PYCR3, and biosynthesis of proline.
View Article and Find Full Text PDFPredator-induced prey dispersal can cause hump-shaped density-area relationships in prey populations.
J Math Biol
January 2024
Department of Mathematics and Statistics, University of North Carolina Greensboro, Greensboro, NC, 27412, USA.
Predation can both reduce prey abundance directly (through density-dependent effects) and indirectly through prey trait-mediated effects. Over the years, many studies have focused on describing the density-area relationship (DAR). However, the mechanisms responsible for the DAR are not well understood.
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