AI Article Synopsis
- Entamoeba histolytica is the main protozoan causing amoebiasis, a severe illness second only to malaria.
- Previous antiamoebic agents based on heterocyclic compounds have been developed, but many only show moderate effectiveness.
- This digest Letter reviews new findings on antiamoebic agents from 2011 to 2016, focusing on various classes of heterocyclic compounds.
Article Abstract
A large number of protozoans infect humans but Entamoeba histolytica is the only organism responsible for causing amoebiasis, a deadly disease after malaria. Numerous heterocycle-based antiamoebic agents have been previously synthesized as E. histolytica inhibitors and while some of these agents have shown moderate activity, the search for a novel and ideal antiamoebic compound is still ongoing. In this digest Letter, we present the latest data on antiamoebic agents from 2011 to 2016 based on the different classes of heterocyclic agents.
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| http://dx.doi.org/10.1016/j.bmcl.2016.09.040 | DOI Listing |
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