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- * The most common symptoms were growth retardation (42.5%) and hematuria (53.8%), with 70% of patients showing renal failure at diagnosis, which was confirmed via ultrasound.
- * Primary hyperoxaluria type 1 (65%) and distal renal tubular acidosis (20%) were the main causes, highlighting the need for early diagnosis and intervention to prevent further kidney damage.
Article Abstract
Background Nephrocalcinosis is rare in children. Its etiologies are multiple. The aim of this study was to analyze the etiology of nephrocalcinosis in Tunisian children. Methods This retrospective study was conducted in the department of pediatrics in Charles Nicolle Hospital during a period of 10 years (2001-2010). Results There were 40 children. The mean age was 3.5 years. The most common signs and symptoms at presentation were growth retardation (42.5%) and hematuria (53.8%). At presentation, renal failure was detected in 70% of patients. The diagnosis of nephrocalcinosis was performed by ultrasonography. The etiology of nephrocalcinosis included primary hyperoxaluria type 1 (65%) and distal renal tubular acidosis (20%). A progression to renal insufficiency was observed in 18 cases. Conclusion Primary oxaluria is the principal cause of nephrocalcinosis; early diagnosis and treatment are mandatory as they help limiting renal function deterioration.
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Aim: To analyze the clinical, genetic, and evolutionary characteristics of type 1 primary hyperoxaluria with pediatric onset.
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Article Synopsis
- * The most common symptoms were growth retardation (42.5%) and hematuria (53.8%), with 70% of patients showing renal failure at diagnosis, which was confirmed via ultrasound.
- * Primary hyperoxaluria type 1 (65%) and distal renal tubular acidosis (20%) were the main causes, highlighting the need for early diagnosis and intervention to prevent further kidney damage.
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