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Serum peroxiredoxin-4, a biomarker of oxidative stress, associates with new-onset chronic kidney disease: A population-based cohort study.
Redox Biol
November 2024
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Background: Chronic Kidney Disease (CKD), is often detected late due to its asymptomatic nature in the early stage of the disease. Overproduction of reactive oxygen species contributes to various pathological processes through oxidative stress (OS), impacting on cellular structures and functions with previous studies suggesting a link between OS and CKD progression. This study investigated the association between serum peroxiredoxin-4 (Prx4), a biomarker of oxidative stress, and the development of CKD in the general population.
View Article and Find Full Text PDFThe role of Proenkephalin A 119-159 in the detection of acute kidney injury after open thoracoabdominal aortic repair.
Vasa
January 2024
Department of Vascular Surgery, European Vascular Center Aachen-Maastricht, RWTH University Hospital Aachen, Germany.
Acute kidney injury (AKI) after open thoracoabdominal aortic aneurysm repairs (TAAA) is a common postoperative complication, associated with increased mortality and morbidity. Early detection and management of the kidney tissue damage remains of paramount importance. The aim of this prospectively conducted, observational trial was to evaluate the clinical applicability of Proenkephalin A 119-159 (penKid) for the detection of postoperative AKI.
View Article and Find Full Text PDFEarly predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels.
Clin Chem Lab Med
October 2022
Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Article Synopsis
- The study investigates the use of urinary S100B protein as a biomarker for early detection of brain injury in infants suffering from hypoxic-ischemic encephalopathy (HIE), comparing it to brain MRI results.
- Urine samples were collected in a cohort of 74 HIE neonates receiving therapeutic hypothermia, with S100B concentrations showing a correlation with MRI patterns at the first urine sample.
- High levels of S100B in urine after birth can reliably predict brain injury, suggesting it could be valuable for clinical decision-making regarding HIE treatment.
Development of a microplate duplex immunoassay to simplify detection of growth hormone doping: Proof of concept.
Drug Test Anal
April 2022
Département des Analyses, Agence Française de Lutte contre le Dopage (AFLD), Châtenay-Malabry, France.
The World Anti-Doping Agency (WADA) prohibits athletes from using recombinant growth hormone (GH). The validated method used in antidoping laboratories for the direct detection of exogenous GH in serum requires two immunoluminometric assays (ILMAs): The first mainly measures the concentration of the full-length (22 kDa) form of GH (recGH), and the second measures concentrations of multiple GH fragments produced by the pituitary gland (22 kDa, 20 kDa and other forms) (pitGH). The tube-by-tube analysis is laborious.
View Article and Find Full Text PDFPlasma Copeptin and Risk of Lower-Extremity Amputation in Type 1 and Type 2 Diabetes.
Diabetes Care
December 2019
INSERM, UMRS 1138, Cordeliers Research Center, Paris, France.
Objective: Diabetes is the leading cause of nontraumatic lower-extremity amputations (LEAs). Identification of patients with foot ulcers at risk for amputation remains clinically challenging. Plasma copeptin, a surrogate marker of vasopressin, is associated with the risk of cardiovascular and renal complications in diabetes.
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