We demonstrate the use of two TM resonant cavities to generate ultrashort electron pulses and subsequently measure electron energy losses in a time-of-flight type of setup. The method utilizes two synchronized microwave cavities separated by a drift space of 1.45 m. The setup has an energy resolution of 12 ± 2 eV FWHM at 30 keV, with an upper limit for the temporal resolution of 2.7 ± 0.4 ps. Both the time and energy resolution are currently limited by the brightness of the tungsten filament electron gun used. Through simulations, it is shown that an energy resolution of 0.95 eV and a temporal resolution of 110 fs can be achieved using an electron gun with a higher brightness. With this, a new method is provided for time-resolved electron spectroscopy without the need for elaborate laser setups or expensive magnetic spectrometers.
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http://dx.doi.org/10.1063/1.4962698 | DOI Listing |
Chemphyschem
January 2025
Deutsches Krebsforschungszentrum, Translational Molecular Imaging, Im Neuenheimer Feld 223, 69120, Heidelberg, GERMANY.
Chemical exchange saturation transfer (CEST) improves the sensitivity of NMR but depending on the spin exchange kinetics, it can require substantial RF energy deposition to label magnetization. Potential side effects like RF-induced heating may occur and must be monitored. Here, we explore the parameter space considering not only undesired heating but efficient CEST build-up (depolarization rate), spectral resolution (line width), and subsequent effects like changes in chemical shifts of CEST responses must be considered, too.
View Article and Find Full Text PDFSmall
January 2025
Leibniz-Institut für Polymerforschung e. V, Hohe Str. 6, 01069, Dresden, Germany.
Polyelectrolyte brushes (PEBs) undergo conformational transitions due to changes in pH and/or ionic strength, which is leveraged as smart surfaces and on-demand drug-release systems. However, probing conformational transitions of functional PEBs has remained challenging due to low spatiotemporal resolution of characterization methods. Herein, fluorescently-coupled PEBs are devised that give rise to Förster Resonance Energy Transfer (FRET) intrinsically coupled to conformational transitions of chains.
View Article and Find Full Text PDFNat Commun
January 2025
Center for Electron Microscopy, South China University of Technology, Guangzhou, China.
Electron ptychography, recognized as an ideal technique for low-dose imaging, consistently achieves deep sub-angstrom resolution at electron doses of several thousand electrons per square angstrom (e/Å) or higher. Despite its proven efficacy, the application of electron ptychography at even lower doses-necessary for materials highly sensitive to electron beams-raises questions regarding its feasibility and the attainable resolution under such stringent conditions. Herein, we demonstrate the implementation of near-atomic-resolution ( ~ 2 Å) electron ptychography reconstruction at electron doses as low as ~100 e/Å, for metal-organic frameworks (MOFs), which are known for their extreme sensitivity.
View Article and Find Full Text PDFLight Sci Appl
January 2025
Institute of Modern Optics, Nankai University, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Tianjin, 300350, China.
A stacked metamaterial MEMS (meta-MEMS) chip is proposed, which can perfectly absorb electromagnetic waves, convert them into mechanical energy, drive movement of the optical micro-reflectors array, and detect millimeter waves. It is equivalent to using visible light to image a millimeter wave. The meta-MEMS adopts the design of upper and lower chip separation and then stacking to achieve the "dielectric-resonant-air-ground" structure, reduce the thickness of the metamaterial and MEMS structures, and improve the performance of millimeter wave imaging.
View Article and Find Full Text PDFPhys Med Biol
January 2025
Physics of Molecular Imaging Systems, RWTH Aachen University, Forckenbeckstraße 55, Aachen, NRW, 52074, GERMANY.
Integrating time-of-flight (ToF) measurements in radiography and computed tomography (CT) enables an approach for scatter rejection in imaging systems that eliminates the need for anti-scatter grids, potentially increasing system sensitivity and image quality. However, present hardware dedicated to the time-correlated measurement of X-rays is limited to a small scale and low density. A switch to highly integrated electronics and detectors is needed to progress towards a medium-scale system capable of acquiring images, while offering a timing resolution below 300 ps FWHM to achieve scatter rejection comparable to current grids.
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