Background: Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders.
Aims: To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 () and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder.
Method: Frequencies of manic and depressive episodes between carriers and non-carriers of the effective rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (=215).
Results: rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence.
Conclusions: rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients.
Declaration Of Interest: None.
Copyright And Usage: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.
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| http://dx.doi.org/10.1192/bjpo.bp.116.002881 | DOI Listing |
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