Evaluation of "Dream Herb," , for Nephrotoxicity Using Human Kidney Proximal Tubule Cells.

J Toxicol

Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), US Food and Drug Administration (US FDA), Neurotoxicology and In Vitro Toxicology Branch (NIVTB), 8301 Muirkirk Road, Laurel, MD 20708, USA.

Published: September 2016

A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. "Dream herb," , has long been used in traditional folk medicine for a variety of purposes and is currently being marketed in the US for medicinal purposes, including diabetes treatment. Despite the inherent vulnerability of the renal system to xenobiotic toxicity, there is a lack of safety studies on the nephrotoxic potential of this herb. Additionally, the high frequency of diabetes-associated kidney disease makes safety screening of for safety especially important. We exposed human proximal tubule HK-2 cells to increasing doses of this herb alongside known toxicant and protectant control compounds to examine potential toxicity effects of relative to control compounds. We evaluated both cellular and mitochondrial functional changes related to toxicity of this dietary supplement and found that even at low doses evidence of cellular toxicity was significant. Moreover, these findings correlated with significantly elevated levels of nephrotoxicity biomarkers, lending further support for the need to further scrutinize the safety of this herbal dietary supplement.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040790PMC
http://dx.doi.org/10.1155/2016/9794570DOI Listing

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There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied. The objective of this work was to determine the toxic effect of the aqueous extract of (), known popularly as "dream herb" and in order to validate its safety. the extract had moderate toxicity on the extract induced eryptosis of 73% at a concentration of 100 g·mL and it inhibited CYP3A by 99% at a concentration of 375 g/mL.

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Evaluation of "Dream Herb," , for Nephrotoxicity Using Human Kidney Proximal Tubule Cells.

J Toxicol

September 2016

Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), US Food and Drug Administration (US FDA), Neurotoxicology and In Vitro Toxicology Branch (NIVTB), 8301 Muirkirk Road, Laurel, MD 20708, USA.

A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. "Dream herb," , has long been used in traditional folk medicine for a variety of purposes and is currently being marketed in the US for medicinal purposes, including diabetes treatment. Despite the inherent vulnerability of the renal system to xenobiotic toxicity, there is a lack of safety studies on the nephrotoxic potential of this herb.

View Article and Find Full Text PDF

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