AI Article Synopsis
- The Gly482Ser gene polymorphism in the PGC-1α gene affects susceptibility to diabetes and obesity and plays a role in how exercise influences metabolism.
- A 12-week study with 119 participants over 65 years examined the impact of exercise training at lactate threshold intensity on cholesterol levels.
- Results showed that individuals with the Gly/Gly genotype experienced significant reductions in total and low-density lipoprotein cholesterol, indicating this genotype may enhance the benefits of moderate exercise in older adults.
Article Abstract
Muscle peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1)α gene expression is influenced by the Gly482Ser gene polymorphism, which is a candidate genetic risk factor for diabetes mellitus and obesity. This study investigated the effects of PGC-1 gene Gly482Ser polymorphisms on alterations in glucose and lipid metabolism induced by exercise training. A 12-week intervention study was performed for 119 participants who were more than 65 years of age and completed exercise training at lactate threshold intensity. Total cholesterol and low-density lipoprotein cholesterol were significantly reduced in Gly/Gly but not in Gly/Ser and Ser/Ser participants after exercise. The Gly/Gly genotype of the PGC-1 gene Gly482Ser polymorphism influences the effects of moderate-intensity exercise training on low-density lipoprotein cholesterol and total cholesterol concentrations in older people.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717479 | PMC |
| http://dx.doi.org/10.1007/s12576-016-0491-y | DOI Listing |
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