AI Article Synopsis
- - Resveratrol is a natural compound produced by plants under stress, showing potential health benefits against various diseases, including neurological and autoimmune conditions.
- - Research on non-obese diabetic (NOD) mice, a model for Sjögren's syndrome, revealed that resveratrol increases saliva secretion and boosts Sirt1 activity, although it does not impact inflammatory cell infiltration.
- - The study found that resveratrol enhances the expression of the anti-inflammatory cytokine IL-10 in salivary glands, suggesting its potential as a novel treatment for salivary dysfunction in Sjögren's syndrome.
Article Abstract
Resveratrol is a natural polyphenol produced by plants in response to environmental stress. This compound has been shown to have pharmacological effects against a wide range of diseases including neurological, hepatic, cardiovascular and autoimmune conditions. The non-obese diabetic (NOD) mouse, in which loss of lacrimal and salivary gland function occurs, has been studied as an animal model for Sjögren's syndrome. In this study, we confirmed that administration of resveratrol results in increased secretion of saliva in NOD mice. Although resveratrol enhanced Sirt1 activity, inflammatory cell infiltration was not affected. Moreover, expression of the anti-inflammatory cytokine IL-10 in salivary glands was enhanced in the resveratrol-administered group. Thus, we confirmed a novel therapeutic effect for resveratrol on salivary dysfunction in Sjögren's syndrome.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018577 | PMC |
| http://dx.doi.org/10.3164/jcbn.16-31 | DOI Listing |
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