AI Article Synopsis
- - Hydrogen sulfide (HS) is traditionally seen as toxic but can have beneficial physiological effects and is produced naturally in the body.
- - HS can easily move across biological membranes and has chemical reactivity similar to thiols, though it forms different products; it interacts with oxidants and affects mitochondrial function.
- - The reactions of HS with oxidized thiols create persulfides, which have increased nucleophilicity and unique chemical properties that may play a role in its biological effects.
Article Abstract
Hydrogen sulfide (HS) has been traditionally considered to be a toxic molecule for mammals. However, it can be formed endogenously and exert physiological effects with potential health benefits. HS can partition two-fold in biological membranes and traverse them rapidly, diffusing between compartments. HS reactivity has similarities to that of thiols, although it is less nucleophilic than thiols and it can form different products. HS can react with oxidants derived from the partial reduction of oxygen, but direct scavenging is unlikely to explain HS protective actions. Important effects are exerted on mitochondria including the stimulation or the inhibition of the electron transport chain. Possible mechanisms for unleashing biological consequences are the reactions with metal centers and with thiol oxidation products. The reactions of HS with disulfides (RSSR) and sulfenic acids (RSOH) lead to the formation of persulfides (RSSH). Persulfides have enhanced nucleophilicity with respect to the corresponding thiol, consistent with the alpha effect. Besides, the inner and outer sulfurs can both act as electrophiles. In this review, we describe the reactions of HS with oxidized thiol products and the properties of the persulfides formed in the context of the chemical biology of HS.
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| http://dx.doi.org/10.1016/j.abb.2016.09.018 | DOI Listing |
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