Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2522/ptj.2016.mcmillan.lecture | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cancer vaccine designed from homologous ferritin-based fusion protein with enhanced DC-T cell crosstalk for durable adaptive immunity against tumors.
Bioact Mater
April 2025
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, PR China.
Peptide vaccines based on tumor antigens face the challenges of rapid clearance of peptides, low immunogenicity, and immune suppressive tumor microenvironment. However, the traditional solution mainly uses exogenous substances as adjuvants or carriers to enhance innate immune responses, but excessive inflammation can damage adaptive immunity. In the current study, we propose a straightforward novel nanovaccine strategy by employing homologous human ferritin light chain for minimized innate immunity and dendritic cell (DC) targeting, the cationic KALA peptide for enhanced cellular uptake, and suppressor of cytokine signaling 1 (SOCS1) siRNA for modulating DC activity.
View Article and Find Full Text PDFProfiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools.
iScience
January 2025
School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, China.
Cell-cell interactions and communication represent the fundamental cornerstone of cells' collaborative efforts in executing diverse biological processes. A profound understanding of how cells interface through various mediators is pivotal across a spectrum of biological systems. Recent strides in microfluidic technologies have significantly bolstered the precision and prowess in capturing and manipulating cells with exceptional spatial and temporal resolution.
View Article and Find Full Text PDFOpen Rotaxane Surgery: What Molecular Editing Can Offer to Supramolecular Chemistry?
Chempluschem
January 2025
University of Wroclaw: Uniwersytet Wroclawski, Chemistry, 14 F. Joliot-Curie 14, 50383, Wroclaw, POLAND.
The skeletal editing approach represents a paradigm shift in organic synthesis by directly targeting the molecular skeleton instead of relying on often long and complicated series of organic transformations. Recent advancements in nitrogen atom deletion reactions have enabled unprecedented late-stage, precise modifications of bioactive compounds and complex natural products, influencing a seemingly distant field such as supramolecular chemistry. In a recent contribution, the Leigh group demonstrated the extrusion of a nitrogen atom from an axle of a [2]rotaxane, extending the applicability of molecular editing to complex, mechanically interlocked architectures.
View Article and Find Full Text PDFAdvancing protein structure prediction beyond AlphaFold2.
Curr Opin Struct Biol
January 2025
Department of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Accurate prediction of protein structures is essential for understanding their biological functions. The release of AlphaFold2 in 2021 marked a significant breakthrough, delivering unprecedented accuracy. However, challenges remain, particularly for proteins with limited evolutionary data or complex molecular interactions.
View Article and Find Full Text PDFUsing Quantitative Trait Locus Mapping and Genomic Resources to Improve Breeding Precision in Peaches: Current Insights and Future Prospects.
Plants (Basel)
January 2025
The Key Laboratory of the Gene Resources Evaluation and Utilization of Horticultural Crop [Fruit Tree], Ministry of Agriculture, Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China.
Modern breeding technologies and the development of quantitative trait locus (QTL) mapping have brought about a new era in peach breeding. This study examines the complex genetic structure that underlies the morphology of peach fruits, paying special attention to the interaction between genome editing, genomic selection, and marker-assisted selection. Breeders now have access to precise tools that enhance crop resilience, productivity, and quality, facilitated by QTL mapping, which has significantly advanced our understanding of the genetic determinants underlying essential traits such as fruit shape, size, and firmness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!