AI Article Synopsis
- Oct3/4 is a key transcription factor that supports the growth and maintenance of stem cells' unique properties.
- The study focused on how the HPV16 E7 oncoprotein and 17β-estradiol influence the expression of Oct3/4, Sox2, Nanog, and Fgf4, which are crucial for stem cell functions.
- Findings revealed that the E7 oncoprotein increases the levels of these factors and plays a role in cell self-renewal, indicating its importance in promoting cancer stem cell characteristics in cervical cancer.
Article Abstract
Oct3/4 is a transcription factor involved in maintenance of the pluripotency and self-renewal of stem cells. The E7 oncoprotein and 17β-estradiol (E) are key factors in cervical carcinogenesis. In the present study, we aimed to investigate the effect of the HPV16 E7 oncoprotein and E on the expression pattern of Oct3/4, Sox2, Nanog and Fgf4. We also determined whether the E7 oncoprotein is associated with cell self-renewal. The results showed that Oct3/4, Sox2, Nanog and Fgf4 were upregulated by the E7 oncoprotein in vivo and in vitro and implicate E in the upregulation of these factors in vivo. We also demonstrated that E7 is involved in cell self-renewal, suggesting that the HPV16 E7 oncoprotein upregulates Oct3/4, Sox2, Nanog and Fgf4 expression to maintain the self-renewal capacity of cancer stem cells.
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| http://dx.doi.org/10.1016/j.virol.2016.09.020 | DOI Listing |
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