AI Article Synopsis
- Animal models, specifically rhesus macaques, are essential for understanding Zika virus (ZIKV) and developing treatments.
- The study found that after being infected, the macaques showed symptoms like fever and high levels of ZIKV RNA in various bodily fluids.
- The infection primarily targeted organs like the intestines, spleen, and glands, allowing researchers to investigate immune responses and disease progression in a relevant model.
Article Abstract
Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemics of Zika virus (ZIKV). Here we report a non-human primate model using a 2016 contemporary clinical isolate of ZIKV. Upon subcutaneous inoculation, rhesus macaques developed fever and viremia, with robust excretion of ZIKV RNA in urine, saliva, and lacrimal fluid. Necropsy of two infected animals revealed that systematic infections involving central nervous system and visceral organs were established at the acute phrase. ZIKV initially targeted the intestinal tracts, spleen, and parotid glands, and retained in spleen and lymph nodes till 10days post infection. ZIKV-specific immune responses were readily induced in all inoculated animals. The non-human primate model described here provides a valuable platform to study ZIKV pathogenesis and to evaluate vaccine and therapeutics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078627 | PMC |
| http://dx.doi.org/10.1016/j.ebiom.2016.09.022 | DOI Listing |
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