AI Article Synopsis
- The study aimed to assess how chronic kidney disease (CKD) affects patients undergoing percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (DES).
- It analyzed data from 12,426 patients, revealing that those with CKD had a higher risk of target lesion failure and adverse clinical outcomes compared to those with normal kidney function, particularly in severe cases.
- Results indicated that while mild to moderate CKD didn't significantly increase risks, severe CKD and dialysis patients faced notably higher risks, and diabetes further exacerbated these outcomes.
Article Abstract
Objectives: The purpose of this study was to evaluate the clinical impact of chronic kidney disease (CKD) on clinical outcomes in contemporary practice of percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (DES).
Background: Although second-generation DES have improved the safety and efficacy issues in PCI, data regarding the performance of second-generation DES in patients with CKD are still limited.
Methods: We performed a patient-level pooled analysis on 12,426 patients undergoing PCI using second-generation DES from the Korean Multicenter Drug-Eluting Stent Registry. Endpoints were stent-oriented outcomes (target lesion failure [TLF]) and patient-oriented composite outcomes (POCO) during a median follow-up of 35 months. CKD patients were stratified by the estimated glomerular filtration rate (eGFR) from mild CKD to end-stage renal disease patients, and by the coexistence of diabetes mellitus (DM).
Results: A total of 2,927 patients had CKD (23.6%), who showed a significantly higher risk of TLF (adjusted hazard ratio [HR]: 1.50; 95% confidence interval [CI]: 1.21 to 1.86) and POCO (HR 1.34; 95% CI: 1.17 to 1.55) compared to patients with preserved renal function. Stratified analysis by eGFR showed that TLF was not increased in the mild to moderate CKD, whereas severe CKD and dialysis-dependent patients showed significantly higher risk of TLF (HR 2.44; 95% CI: 1.54 to 3.86; HR 3.58; 95% CI: 2.52 to 5.08, respectively). The eGFR threshold of increased clinical events was 40 to 45 ml/min/1.73 m. Among CKD patients, DM CKD patients showed a higher incidence of TLF compared to non-DM CKD patients (HR: 1.82; 95% CI: 1.32 to 2.52), driven by the increase in target vessel-related events.
Conclusions: In the era of second-generation DES, CKD patients were at a significantly higher risk of clinical outcomes only in severe CKD and end-stage renal disease patients.
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| http://dx.doi.org/10.1016/j.jcin.2016.06.051 | DOI Listing |
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