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Gout, a common chronic disease, is characterized by the formation and deposition of monosodium urate (MSU) crystal deposition in articular and nonarticular structures. Osteoarthritis (OA), the most prevalent type of arthritis, is a progressive degenerative joint disease. Previous clinical studies have reported that gout frequently affects OA joints; however, the underlying mechanism remains unidentified.
View Article and Find Full Text PDFRecurrent cholangitis due to an intrahepatic calculus caused by migrated coil for vascular embolization: A case report.
Medicine (Baltimore)
December 2024
Department of Hepatobiliary Pancreatic Surgery, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
Article Synopsis
- Pseudoaneurysms can occur after hepatobiliary and pancreatic surgeries, and catheter interventions are typically the first step in treatment; however, complications from arterial embolization can arise.
- A case study of a 43-year-old male revealed that a dislodged embolization coil caused bile duct stone formation, leading to recurrent cholangitis after previous treatment for a hepatic artery pseudoaneurysm.
- The case highlights the need for clinicians to monitor embolization coil positions in patients and consider coil migration as a potential cause when diagnosing bile duct stones, especially following hepatic artery embolization.
Ectopic recurrence following treatment of arteriovenous malformations in an adult: A case report and review of literature.
World J Radiol
October 2024
Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Background: Digital subtraction angiography (DSA), the gold standard for the diagnosis of intracranial arteriovenous malformations (AVMs), can show clean nidus resection, leading to a perceived cure. Most cases of intracranial AVM recurrence have been reported in pediatric patients. The conventional understanding indicates that AVMs arise when abnormal blood vessels develop between the fourth and eighth weeks of embryonic development, which coincides with the typical period of blood vessel formation in the brain.
View Article and Find Full Text PDFMechanistic study of Nidus Vespae inhibiting gastric cancer in vitro through the JAK2/STAT3 signaling pathway.
J Ethnopharmacol
February 2025
Clinical Oncology Laboratory, Changzhou Tumor Hospital, Changzhou, Jiangsu, China; Medical Oncology Department, Changzhou Tumor Hospital, Changzhou, Jiangsu, China. Electronic address:
Ethnopharmacological Relevance: Nidus Vespae, an animal-derived traditional Chinese medicine, has a long-standing history in treating inflammatory conditions and tumor-related diseases. Notably, Nidus Vespae decoction (NVD) has been shown to inhibit the proliferation of gastric cancer cells, although the underlying mechanisms remain unclear.
Objective: This study aimed to elucidate the efficacy and mechanisms by which NVD exerts its therapeutic effects on gastric cancer.
Bone Destruction-Chemotactic Osteoprogenitor Cells Deliver Liposome Nanomedicines for the Treatment of Osteosarcoma and Osteoporosis.
ACS Nano
October 2024
Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Therapeutic efficacy of skeletal diseases is usually limited by unfavorable drug delivery due to incapable bone targeting and low bone affinity of conventional drug carriers, as well as relatively reduced vascularization and dense structure of bone tissues. Due to CXC chemokine receptor 4 (CXCR4)/CXC chemokine ligand 12 (CXCL12) signal axis-guided recruitment, osteoprogenitor cells (OPCs) can actively migrate to bone disease nidus. Here, drugs-loaded nanoliposomes are prepared and decorated onto OPCs by biotin-streptavidin linkage for precise bone disease targeting and effective drug delivery.
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