The view that the fundamental kind properties are intrinsic properties enjoys reflexive endorsement by most metaphysicians of science. But ontic structural realists deny that there are any fundamental intrinsic properties at all. Given that structuralists distrust intuition as a guide to truth, and given that we currently lack a fundamental physical theory that we could consult instead to order settle the issue, it might seem as if there is simply nowhere for this debate to go at present. However, I will argue that there exists an as-yet untapped resource for arguing for ontic structuralism - namely, the way that fundamentality is conceptualized in our most fundamental physical frameworks. By arguing that physical objects must be subject to the 'Goldilock's principle' if they are to count as fundamental at all, I argue that we can no longer view the majority of properties defining them as intrinsic. As such, ontic structural realism can be regarded as the most promising metaphysics for fundamental physics, and that this is so even though we do not yet claim to know precisely what that fundamental physics is.
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http://dx.doi.org/10.1016/j.shpsa.2016.06.005 | DOI Listing |
Adv Compos Hybrid Mater
January 2025
J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843 USA.
Dosage tolerance is one of the translational challenges of using metformin (Met) in brain therapeutics. This paper presents metal-organic framework (MOF)-74-Mg nanocarriers (NCs) for intranasal (IN) delivery of brain-specific agents with a prolonged release time. We confirmed their excellent biocompatibility (5 mg/mL) and intrinsic fluorescence properties (370/500 nm excitation/emission peak) in Neuro-2A cells.
View Article and Find Full Text PDFMol Neurodegener
January 2025
The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Background: Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biological properties; thus, insights into retinal aging and degeneration may shed light onto similar processes in the brain. Genetic makeup strongly influences susceptibility to age-related retinal disease.
View Article and Find Full Text PDFSci Rep
January 2025
School of Chemistry and Chemical Engineering, Heze University, Heze, 274015, People's Republic of China.
A novel adsorbent ZnAl-LDHs/SiO (ZA/SiO) was prepared by blending urea mixture of ZnSO and Al(SO) while using SiO as a support form. The adsorption properties of ZA/SiO for the removal of toxic metal ions (Cu(II) and Cr(VI)) from water were evaluated. By batch experiment method to investigate the ZA/SiO adsorption of Cu(II) and Cr(VI) solution treatment effect.
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January 2025
National Institute of Plant Genome Research, New Delhi 110067, India.
This study explores the structural adaptations of the CRISPR-Cas9 system in halophilic bacteria, focusing on Cas9 protein of halophilic bacterium Salicibibacter cibi. Protein sequences were analysed using different tools such as ExPASy ProtParam for different physicochemical properties, PONDR web server for disordered regions, and InterPro server and WebLogo for domains. Protein structures were generated using the AlphaFold database, and the quality of the modelled structure was checked through PROCHECK.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
State Key Laboratory of Resource Insects, Southwest University, Chongqing 400716, China. Electronic address:
Wounds are regarded as disruptions in the integrity of human skin tissues, and the process of wound healing is often characterized as protracted and complex, primarily due to the potential infection or inflammation caused by microorganisms. The quest for innovative solutions that accelerate wound healing while prioritizing patient safety and comfort has emerged as a focal point. Within this pursuit, silkworm silk fibroin-a natural polymer extracted from silk cocoons-exhibits a distinctive combination of properties including biocompatibility, biodegradability, superior mechanical strength, water absorption, and low immunogenicity, which align closely with the demands of contemporary wound care.
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