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Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation.
J Neurosci Res
September 2008
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.
An Ig superfamily cell-adhesion molecule, L1, forms an adhesion complex at the cell membrane containing both signaling molecules and cytoskeletal proteins. This complex mediates the transduction of extracellular signals and generates actin-mediated traction forces, both of which support axon outgrowth. The L1 cytoplasmic region binds ezrin, an adapter protein that interacts with the actin cytoskeleton.
View Article and Find Full Text PDFActive surface transport of metabotropic glutamate receptors through binding to microtubules and actin flow.
J Cell Sci
December 2003
Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Institut François Magendie, rue Camille saint Saëns, 33077 Bordeaux, Cedex, France.
Receptors for neurotransmitters are concentrated and stabilized at given sites such as synapses through interactions with scaffolding proteins and cytoskeletal elements. The transport of receptors first involves directed vesicular trafficking of intracellularly stored receptors followed by their targeting to the plasma membrane. Once expressed at the cell surface, receptors are thought to reach their final location by random Brownian diffusion in the plasma membrane plane.
View Article and Find Full Text PDFProbing f-actin flow by tracking shape fluctuations of radial bundles in lamellipodia of motile cells.
Biophys J
July 2000
Department of Materials, ETH Zurich, Schlieren, Switzerland.
We examined the dynamics of radial actin bundles based on time-lapse movies of polarized light images of living neuronal growth cones. Using a highly sensitive computer vision algorithm for tracking, we analyzed the small shape fluctuations of radial actin bundles that otherwise remained stationary in their positions in the growth cone lamellipodium. Using the tracking software, we selected target points on radial bundles and measured both the local bundle orientations and the lateral displacements between consecutive movie frames.
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