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Aldgamycins J-O, 16-Membered Macrolides with a Branched Octose Unit from Streptomycetes sp. and Their Antibacterial Activities. | LitMetric

Aldgamycins J-O, 16-Membered Macrolides with a Branched Octose Unit from Streptomycetes sp. and Their Antibacterial Activities.

J Nat Prod

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.

Published: October 2016

AI Article Synopsis

  • Six new macrolides (aldgamycins J-O) with a unique branched sugar unit were discovered from a Streptomyces strain, alongside two known compounds.
  • The structures of these compounds were investigated using advanced spectroscopic and X-ray techniques, revealing that branched sugars like aldgarose are uncommon in natural products.
  • All isolated compounds were tested for antimicrobial effects, showing that most were effective against the bacteria Staphylococcus aureus and providing insights into their structure-activity relationships.

Article Abstract

Six new 16-membered macrolides with a rare branched octose unit, aldgamycins J-O (1-6), along with two known compounds, swalpamycin B (7) and chalcomycin (8), were isolated from Streptomyces sp. HK-2006-1. Their structures were determined by detailed spectroscopic and X-ray crystallographic analysis. Natural products containing branched sugar units are rare. Aldgaropyranose and decarboxylated aldgaropyranose are branched octoses, specifically aldgarose-type branched octose. Until now, only 11 compounds have been reported to contain an aldgarose-type branched octose. The discovery of aldgamycins J-O (1-6) adds new members of this type of natural product. All the compounds (1-8) herein were tested for antimicrobial activities against Gram-positive Staphylococcus aureus 209P, Gram-negative Escherichia coli ATCC0111, and two fungi, Candida albicans FIM709 and Aspergillus niger R330. Most of these compounds showed antibacterial activity against S. aureus. Their preliminary structure-activity relationships are proposed.

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Source
http://dx.doi.org/10.1021/acs.jnatprod.6b00200DOI Listing

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