AI Article Synopsis
- This study explores a new treatment for atopic dermatitis using a specialized textile therapy that incorporates a herbal medicine within a thermosensitive hydrogel.
- The formulation's effectiveness was influenced by factors like the concentrations of poloxamer 407 and carboxymethyl cellulose sodium, which altered the viscosity and affected the drug release.
- It was found that higher pH levels hindered the release of the drug, while increased temperatures helped, and the drug's release followed a first-order kinetic model, with improved skin permeability when more CMCs were added.
Article Abstract
For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2016.09.036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!