Multidrug-resistant enterococcal nosocomial invasive infections are a rising concern faced by the medical community. Not many options are available to treat these highly virulent organisms. Risk factors for developing these highly resistant organisms include prolonged hospital stay, previous antibiotic use, and immunosuppression. In this article, we report a case of daptomycin-resistant enterococcal native infective endocarditis treated with off-label use of quinupristin-dalfopristin.
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http://dx.doi.org/10.1177/2324709616665408 | DOI Listing |
Front Cell Infect Microbiol
January 2025
Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
() is a Gram-positive bacterium commonly colonizing the skin and mucosa in healthy individuals and hospitalized patients. Traditionally regarded as a contaminant, is now increasingly recognized as a potential cause of clinical infections, especially after the coronavirus disease pandemic. It has emerged as a pathogen implicated in severe infections, including pneumonia, bacteremia, meningitis, artificial joint infections, abdominal infections, and endocarditis.
View Article and Find Full Text PDFEur Heart J Case Rep
January 2025
Department of Cardiology, Clínica Alemana de Santiago, Avenida Manquehue Norte #1499, 7650568 Vitacura, Chile.
Background: Infective endocarditis during pregnancy is a rare condition that compromises the health of both the mother and the foetus, presenting high rates of morbidity and mortality. The clinical manifestations of this disease are varied, with embolic phenomena being a frequent presentation.
Case Summary: We report the case of a Hispanic 37-year-old patient, at 29 weeks of pregnancy, with no known cardiovascular history, who presented with 48 h of sudden mandibular and lingual pain.
BMC Infect Dis
January 2025
Medical Microbiology, Leeds Teaching Hospitals Trust, Leeds, UK.
Background: Guidelines suggest treating fully penicillin-susceptible Enterococcus faecalis strains causing infective endocarditis with amoxicillin combined with gentamicin or ceftriaxone, but clinical evidence to support this practice is limited and monotherapy cohorts were excluded from studies. We describe antibiotic treatment, complications, and outcomes in patients with Enterococcus faecalis infective endocarditis, specifically comparing monotherapy versus combination therapy.
Methods: Retrospective analysis of prospectively collected cohort of patients with definite or possible infective endocarditis from 2 English centres between 2006 and 2021.
BMC Infect Dis
January 2025
Wuming Hospital of Guangxi Medical University, Nanning, China.
Streptococcus suis(SS) infection is a zoonotic acute infectious disease, SS infective endocarditis is relatively rare, there is no case report of Streptococcus suis Serotype 1(SS1) causing mitral valve infection.The rapid progression of this patient's infection and the severe damage to the valve structure differ from the previous understanding of the relatively low virulence of SS1. Early diagnosis and selection of the correct antibiotic treatment according to the drug sensitivity is very important.
View Article and Find Full Text PDFAn aortic periannular abscess (PA) is a critical consequence of infective endocarditis (IE). In our case report, the patient's clinical symptoms were only fever, cough, and shortness of breath. He was then diagnosed with aortic PA, which was overlooked in the initial TTE assessment but later identified through transesophageal echocardiography (TEE).
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