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Ectopic overexpression of DNA-/RNA-binding Alba proteins misregulates virulence gene homeostasis during asexual blood development.
Microbiol Spectr
January 2025
Institute of Bioinformatics and Applied Biotechnology, Bengaluru, Karnataka, India.
Alba domain-containing proteins are ubiquitously found in archaea and eukaryotes. By binding to either DNA, RNA, or DNA:RNA hybrids, these proteins function in genome stabilization, chromatin organization, gene regulation, and/or translational modulation. In the malaria parasite , six Alba domain proteins PfAlba1-6 have been described, of which PfAlba1 has emerged as a "master regulator" of translation during parasite intra-erythrocytic development (IED).
View Article and Find Full Text PDFImproving diagnostics and surveillance of malaria among displaced people in Africa.
Int J Equity Health
January 2025
Department of Research, Toufik's World Organization, Anonova 10, Sumy, 40007, Ukraine.
African communities that have been forced to leave their homes experience a considerably greater susceptibility to malaria as a result of densely populated living conditions, restricted availability of healthcare, and environmental influences. Internally displaced individuals frequently live in large settlements with restricted availability to drinking water, essential sanitation, and medical services, intensifying the spread of malaria. As a result, the occurrence of malaria is significantly more common among refugees and internally displaced individuals compared to those who are not displaced.
View Article and Find Full Text PDFEngaging rural communities in Bangladesh to tackle antimicrobial resistance through the Community Dialogue Approach: a process evaluation protocol for COSTAR project in Cumilla, Bangladesh.
Front Public Health
December 2024
Nuffield Centre for International Health and Development, Leeds Institute for Health Sciences, University of Leeds, Leeds, United Kingdom.
Introduction: Antimicrobial resistance (AMR) is a global problem and is especially threatening for low-and-middle income countries like Bangladesh. The COSTAR (Community-led Solutions to Antimicrobial Resistance) project includes a Randomised Control Trial (RCT) which aims to evaluate the effectiveness of the Community Dialog Approach (CDA) to improve levels of correct and appropriate knowledge and reported practice about antibiotics, antibiotic use, and antibiotic resistance (ABR) from a One Health perspective, among adult community members in 5 selected sub-districts of Cumilla. The CDA is a community engagement approach involving community members in active discussions also known as Community Dialogs (CD), run by local facilitators.
View Article and Find Full Text PDFDetection of Bacterial Infections and Malaria among Blood Culture-Negative Samples of Hospitalized Febrile Patients from a Tertiary Hospital in Ethiopia.
Am J Trop Med Hyg
January 2025
Hirsch Institute of Tropical Medicine, Asella, Ethiopia.
Article Synopsis
- Febrile illnesses are a major health issue in sub-Saharan Africa, often leading to inadequate treatment due to limited diagnostic resources and a wide range of possible pathogens.
- This study focused on evaluating a multiplex polymerase chain reaction (PCR) method for diagnosing febrile diseases in patients at a hospital in Central Ethiopia over two years, testing samples from 511 patients.
- The results showed that while pathogens were detected in only 6.3% of the samples, including Plasmodium and Borrelia, the use of multiplex PCR can still enhance diagnostic capabilities and inform better clinical management in settings with limited resources.
Water Extract of Nakai Inhibits Osteoclast Differentiation and Alleviates Ovariectomy-Induced Bone Loss.
Int J Mol Sci
October 2024
KM Convergence Research Division, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon 34054, Republic of Korea.
Nakai () is a perennial herb traditionally used to treat malaria and fever. Although the pharmacological properties of have been explored in various contexts, its effects on bone diseases, such as osteoporosis, remain poorly studied. In this study, we investigated the effects of water extracts of (WEPK) on osteoclasts, which play a crucial role in bone remodeling, and an ovariectomized (OVX) mouse model, which mimics osteoporosis.
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