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Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.
PLoS One
January 2020
Department of Biomedical Science, Charles E. Schmidt College of Science, Florida Atlantic University, Jupiter, FL United States of America.
Dopamine (DA) is a neurotransmitter with actions across phylogeny that modulate core behaviors such as motor activity, reward, attention, and cognition. Perturbed DA signaling in humans is associated with multiple disorders, including addiction, ADHD, schizophrenia, and Parkinson's disease. The presynaptic DA transporter exerts powerful control on DA signaling by efficient clearance of the neurotransmitter following release.
View Article and Find Full Text PDFAddiction to RUNX in lymphoma.
Aging (Albany NY)
September 2016
Molecular Oncology Laboratory, Centre for Virus Research, Institute of Infection, Immunity and Inflammation, University of Glasgow, Bearsden Glasgow G61 1QH, UK.
Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model.
Oncotarget
April 2016
Molecular Oncology Laboratory, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
The Runx genes function as dominant oncogenes that collaborate potently with Myc or loss of p53 to induce lymphoma when over-expressed. Here we examined the requirement for basal Runx1 activity for tumor maintenance in the Eµ-Myc model of Burkitt's lymphoma. While normal Runx1fl/fl lymphoid cells permit mono-allelic deletion, primary Eµ-Myc lymphomas showed selection for retention of both alleles and attempts to enforce deletion in vivo led to compensatory expansion of p53null blasts retaining Runx1.
View Article and Find Full Text PDFGlial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development.
Int J Dev Neurosci
November 2010
Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, 04044-020 São Paulo, SP, Brazil.
Cerebellum controls motor coordination, balance, eye movement, and has been implicated in memory and addiction. As in other parts of the CNS, correct embryonic and postnatal development of the cerebellum is crucial for adequate performance in the adult. Cellular and molecular defects during cerebellar development can lead to severe phenotypes, such as ataxias and tumors.
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