A new α-pyrone derivative, phomopyrone A (1), together with two known compounds (2-3), was isolated from the culture of the mangrove endophytic fungus Phomopsis sp. HNY29-2B. Their structures were determined by detailed analysis of spectroscopic data. The configuration of 1 was further confirmed by X-ray diffraction. All isolated compounds were evaluated for antibacterial and antioxidative activities. Compound 2 exhibited antibacterial activities with minimal inhibition concentration (MIC) values of 25 and 50 μM against Bacillus subtilis and Pseudomonas aeruginosa, and compound 3 showed activities against Staphylococcus aureus and B. subtilis with MIC values of 25 and 50 μM, respectively.
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