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Mortality prediction after major surgery in a mixed population through machine learning: a multi-objective symbolic regression approach.
Anaesthesia
January 2025
Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Introduction: Understanding 1-year mortality following major surgery offers valuable insights into patient outcomes and the quality of peri-operative care. Few models exist that predict 1-year mortality accurately. This study aimed to develop a predictive model for 1-year mortality in patients undergoing complex non-cardiac surgery using a novel machine-learning technique called multi-objective symbolic regression.
View Article and Find Full Text PDFThe increasing global burden of cancer: implications for anaesthesia and peri-operative medicine.
Anaesthesia
January 2025
Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Introduction: Most patients with cancer will require surgery at some point in their lifetime. As the global burden of cancer continues to increase, changes and challenges in cancer epidemiology and care are also borne peri-operatively.
Methods: Due to its broad scope, a formal systematic electronic literature search was not performed.
Patient-centred outcome measures for oncological surgery: a narrative review.
Anaesthesia
January 2025
Anaesthetic Department, Royal Surrey Hospital Foundation Trust, Guildford, UK.
Introduction: Peri-operative medicine is becoming increasingly relevant in the context of managing frail patients with cancer. This paper outlines how demographic shifts in populations are affecting cancer incidence and frailty rates, the relevance this holds to the management of cancer care, and the outcome measures that should be used to gauge best clinical practice to ensure patient-centred care.
Methods: A targeted literature review was conducted using the search terms 'surgical oncology', 'outcomes', 'frailty', 'quality of life' and 'end of life' from 10 to 17 June 2024.
Cardiotoxicity and peri-operative considerations in immune checkpoint inhibitor and chimeric antigen receptor T-cell therapy: a narrative review.
Anaesthesia
January 2025
Department of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Burlington, MA, USA.
Introduction: Immunotherapy has transformed cancer treatment, particularly with immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy. Despite their efficacy, these therapies can induce cardiotoxicity, presenting significant clinical challenges. Immune checkpoint inhibitors can cause myocarditis; pericarditis; arrhythmias; and myocardial infarction through immune-mediated inflammation.
View Article and Find Full Text PDFThe evolution and key components of onco-anaesthesia: a narrative review.
Anaesthesia
January 2025
Department of Onco-anaesthesia and Palliative Medicine, AIIMS, New Delhi, India.
Introduction: Onco-anaesthesia is a specialised branch of anaesthesia dedicated to enhancing outcomes, prioritising patient safety and improving the overall care of patients with cancer during surgery. We outline the global epidemiology of cancer, emphasising the necessity for this subspecialty, and discuss the criteria supporting its establishment.
Methods: We performed searches of electronic databases to identify relevant peer-reviewed publications.
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